Impact of Aged Tumor Microenvironment and Chemosensitivity on Sub-types of Ovarian Cancer
February 24, 2025
Research JournalBy Lila Taylor1, Dr. Zhiqing Huang2
1 2Duke University
Synopsis
This study investigates how aging effects the growth of ovarian cancer, as well as sensitivity of different ovariancancers to various chemotherapies. By growing and aging non-cancerous cells to mimic the environmentovarian cancer would see inside the human body, we were able to find that in the lab, ovarian cancer cellsgrew worse in the “older” condition compared to the “young” environment. Additionally, we identified achemotherapy called ibrutinib that effectively targets slower growing ovarian cancer cell lines.